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Results for "

lipoxygenase product

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

5

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N11058
    Damnacanthol

    		Lipoxygenase NO Synthase Inflammation/Immunology
    Damnacanthol is a natural product that can be isolated from Damnacanthus major . Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells .
    Damnacanthol
  • HY-113913
    12(S)-HPEPE

    		Prostaglandin Receptor Inflammation/Immunology
    12(S)-HPEPE is a lipoxygenase product and an intermediate metabolite that leads to downregulation of PGHS-2 and has potential anti-inflammatory activity. 12(S)-HPEPE reduces interleukin 1h (IL-1h)-induced PGHS-2 expression in human lung microvascular endothelial cells .
    12(S)-HPEPE
  • HY-U00438
    LP117

    		Lipoxygenase Inflammation/Immunology
    LP117 is a novel and potent inhibitor of 5-Lipoxygenase (5-LO) product synthesis with an IC50 of 1.1 μM.
    LP117
  • HY-14164R
    Zileuton (Standard)

    A 64077 (Standard); Abbott 64077 (Standard)

    		 Lipoxygenase Ferroptosis Inflammation/Immunology Cancer
    Zileuton (Standard) is the analytical standard of Zileuton. This product is intended for research and analytical applications. Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
    Zileuton (Standard)
  • HY-125122
    Mulberrofuran A

    		Others Inflammation/Immunology
    Mulberrofuran A is a natural product, that can be isolated from the root bark of mulberry tree. Mulberrofuran A inhibits the formations of 12-hydroxy-,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products), but it increases the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) (12-lipoxygenase product) .
    Mulberrofuran A
  • HY-W747564
    (+/-)12-HpETE

    		Endogenous Metabolite Cardiovascular Disease
    (+/-)12-HpETE is a 12-hydroxyicosatetraenoic acid product by lipoxygenase. (+/-)12-HpETE has vasodilator action .
    (+/-)12-HpETE
  • HY-N2513R
    β-Boswellic acid (Standard)

    		Lipoxygenase DNA/RNA Synthesis Cancer
    β-Boswellic acid (Standard) is the analytical standard of β-Boswellic acid. This product is intended for research and analytical applications. β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation . β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells .
    β-Boswellic acid (Standard)
  • HY-113884B
    (S)-Coriolic acid

    13(S)-HODE

    		 PPAR Mitochondrial Metabolism Inflammation/Immunology Cancer
    (S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury .
    (S)-Coriolic acid
  • HY-155407
    ALR-6

    		FLAP Inflammation/Immunology
    ALR-6 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-6 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM and has no significant effect on direct inhibition of 5-LOX .
    ALR-6
  • HY-N2513
    β-Boswellic acid

    		Lipoxygenase DNA/RNA Synthesis Cancer
    β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation . β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells .
    β-Boswellic acid
  • HY-116124
    17(S)-HpDHA

    		Lipoxygenase Others
    17(S)-HpDHA is the main 15-Lipoxygenase (LOX) isoenzyme: h15-LOX-1 and h15-LOX-2 and docosahexaenoic acid (DHA). product. 17(S)-HpDHA negatively regulates epoxide synthesis via allosteric regulation. 17(S)-HpDHA also inhibits platelet aggregation with an EC50 of approximately 1 μM .
    17(S)-HpDHA
  • HY-113434A
    5(R)-HETE

    		Others Inflammation/Immunology
    5(R)-HETE is a lipoxygenase product of arachidonic acid. 5(R)-HETE is an? inducer of neutrophil migration through endothelial and epithelial barriers. 5(R)-HETE is important in mediating lung inflammatory processes .
    5(R)-HETE
  • HY-134511
    15(S)-HpEPE

    		Prostaglandin Receptor Inflammation/Immunology Cancer
    15(S)-HpEPE is a product of lipoxygenase hydrolysis of unsaturated fatty acids (PUFA) and is a potential inhibitor of prostaglandin H synthase 2 (PGHS-2). 15(S)-HpEPE can downregulate the expression of PGHS-2 .
    15(S)-HpEPE
  • HY-155408
    ALR-27

    		FLAP Inflammation/Immunology
    ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes .
    ALR-27
  • HY-128171
    Diflapolin
    1 Publications Verification

    		 FLAP Epoxide Hydrolase Inflammation/Immunology
    Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s of  30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC50=20 nM) .
    Diflapolin
  • HY-123023
    12(S)-HETE D8

    		Others Cancer
    12(S)-HETE D8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14 and 15 positions. 12(S)-HETE D8 is intended for use as an internal standard for the quantification of 12(S)-HETE by GC- or LC-mass spectrometry (MS). 12(S)-HETE D8 is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 µM.
    12(S)-HETE D8

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